Vortioxetine Impurity 146 TFA CAS 1429908-33-7 (free base)
| CAS No. | 1429908-33-7 (free base) |
| Molecular Formula | C18H20N2O2S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Vortioxetine Impurity 146 TFA (CAS 1429908-33-7 (free base)), a pharmacopoeial impurity reference standard (molecular formula C18H20N2O2SC2HF3O2, MW 442.45 g/mol) used for the identification and quantification of trace impurities in APIs.
Vortioxetine Impurity 146 TFA (C18H20N2O2SC2HF3O2) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO manufactures Vortioxetine Impurity 146 TFA under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H20N2O2S C2HF3O2 |
| Molecular Weight | 442.45 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Vortioxetine Standards
- Vortioxetine Impurity 63 (CAS 1009-85-4)
- Vortioxetine Impurity 2 (CAS 1011-13-8)
- Vortioxetine Impurity 89 (CAS 1019453-85-0)
- Vortioxetine Impurity 116 (CAS 102439-46-3)
- Vortioxetine Impurity 88 (CAS 103-19-5)
- Vortioxetine Impurity 60 (CAS 1049755-55-6)
- Vortioxetine Impurity 48 (CAS 105456-67-5)
- Vortioxetine Impurity 101 (CAS 107832-66-6)
Recommended Standards
- Etomidate EP Impurity A (CAS 7036-56-8)
- Esomeprazole Impurity 117 (CAS 1427498-68-7)
- Indobufen Impurity 39 (CAS 13048-83-4)
- Posaconazole Impurity 116 (CAS 151670-13-2)
- 3-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-pyrazole (CAS 1196879-97-6)
- 2,3-Difluoro-6-methylpyridine (CAS 1227579-04-5)
- 5-Fluoro-2-(hydroxymethyl)-4-methylbenzimidazole (CAS 1936068-82-4)
- (E)-2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-2-(thiophen-2-yl)acetaldehyde O-methyl oxime (CAS 338770-60-8)
- N-Hydroxy-2-(naphthalen-1-yloxy)acetimidamide (CAS 884504-65-8)
- Liraglutide Impurity 30 (CAS CATO-C4X-199230)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com